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Quddos et al

District Court judge denied a motion for a preliminary injunction that would have allowed certain compounding pharmacies to continue producing compounded versions of tirzepatide

Advise discontinuation of GLP-1 RAs prior to conception in accordance with pharmacokinetic half-life

The response

Conditions that disrupt intestinal neuromuscular signaling can cause secondary constipation (eg, multiple sclerosis, Parkinsons disease, spinal cord injury, diabetic neuropathy, and stroke) (Basilisco 2013